Results
| PMID | 9049281 |
| Gene Name | IGF1 |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 18 |
| Population details | 18 infertile patients for the problem of infertility |
| Sex | Female |
| Associated genes | IGF-I, IGF-IR |
| Other associated phenotypes |
Endometriosis |
|
Acta Obstet Gynecol Scand. 1997 Feb;76(2):112-7. Chang, S Y| Ho, Y S Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Kaohsiung, Republic of China. BACKGROUND: The purpose of this study was to investigate unprecedentedly immunohistochemical localization of insulin-like growth factor I, insulin-like growth factor I receptor and insulin-like growth factor II in endometriotic tissue, and to compare staining intensity with that of endometrium obtained simultaneously. METHODS: Endometriotic and corresponding endometrial tissue samples were obtained during operative laparoscopy from eighteen infertile patients for the problem of infertility. Semiquantitative scoring was used for analysis of results. RESULTS: It was demonstrated that insulin-like growth factor I and insulin-like growth factor I receptor were present in both endometriotic and endometrial tissues. In contrast, there was little insulin-like growth factor II present in either ectopic or eutopic endometrial tissue. For insulin-like growth factor I and insulin-like growth factor I receptor, the immunostaining score was similar between ectopic and eutopic endometrial tissues. There was no significant difference in immunostaining score between glandular epithelium and stromal cells. CONCLUSIONS: insulin-like growth factor I and insulin-like growth factor I receptor could be demonstrated immunohistochemically in both endometriotic and endometrial tissues. Mesh Terms: Adult| Endometriosis/*metabolism| Endometrium/*chemistry| Female| Humans| Immunohistochemistry| Insulin-Like Growth Factor I/*analysis| Insulin-Like Growth Factor II/*analysis| Peritoneal Diseases/*metabolism| Receptor, IGF Type 1/*analysis|DA 19 |
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